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Tramadol is a synthetic chemical compound that is used to treat pain and discomfort. It is normally an ingested medication that works centrally instead of locally. While it is used as a pain reliever, it is often not prescribed to handle very severe pain. Ideally, it is given for mid-level to mid-level severe pain. Given the wide range of pain thresholds it can handle, it is prescribed for quite a lengthy list of painful or uncomfortable conditions such as fibromyalgia, motor neurone disease, restless legs syndrome, rheumatoid arthritis, among many other conditions. In this respect, Tramadol is prescribed similar to pain reliever drug classes like codein.



What class of chemical compound is Tramadol?

Tramadol, in of itself, is quite a relatively weak receptor agonist of µ-opioid. However, the body metabolizes Tramadol to O-desmethyltramadol which is a much more powerful receptor agonist of µ-opioid. Among users of the IV version of Tramadol, this more powerful metabolized version is very similar to the metabolized form of codeine-morphine. Still, there are many other compounds on the market that feature a higher level of potency in terms of µ-opioid receptor agonist activity. Interestingly enough, Tramadol also impacts the body’s norepinephrine and serotonin levels. It inhibits the reuptake of these compounds. Since inhibiting the reuptake of these brain neurotransmitters has been used to treat conditions like phobias, anxiety, and depression, the idea of using Tramadol as an anti-phobia, antidepressant, or antianxiety medication has been floated. Physicians have not been entirely warm to this idea and this indication for Tramadol has not been approved. Instead, health professionals suggest that Tramadol’s serotonin and norepinephrine reuptake inhibition qualities be utilized only in unique or very limited circumstances. These professionals suggest that this limited use of Tramadol should only be considered if other treatments don’t produce desired results in treating phobias, depression, or anxiety. In such a circumstance, Tramadol’s usage as a serotonin and norepinephrine reuptake inhibitor should only be done under the strict supervision of a qualified psychiatrist.

In terms of structure, Tramadol looks similar to codeine albeit a stripped-down variant. How are they alike? Both codeine and tramadol have a shared 3-methyl ether structure. Both compounds are metabolized in the same pathway in the liver. Both are metabolized by the liver to produce stronger compounds. In the case of codeine, the final form is morphine while in tramadol, the final metabolized form is O-desmethyltramadol In terms of observed effect, patients don’t feel any subjective difference in potency in the IV form of morphine and tramadol.

Tramadol is off-patent in the US and is available in generic form under a number of brands. Many different manufacturers produce Tramadol under their own brands. Some of the bigger generic manufacturers of Tramadol are: Teva, APO, Pur-Pak, Mallinckrodt, Cor Pharma, Mylan, Caraco, Amneal, and many others. The most common generic dosage size and form are tablets in 50mg doses. Tramadol also has brand name versions on the market. These are Ultram and Ultram ER.

Buy Tramadol Online

To reduce acute pain you can buy Tramadol. Tramadol is an opioid analgesic with a rapid and intense analgesic effect.

Unlike standard analgesics, Tramadol affects receptors of the central nervous system and considerably raises a pain threshold. Tramadol has the directed effect on a spinal cord, therefore conductivity of painful impulses on receptors of the central nervous system is decreased.

Tramadol has a general analgesic effect and can suppress pain in several centers. Due to this feature, Tramadol is actively used to reduce acute pain in case of inflammatory diseases, cancer pains (metastasis).

Tramadol can reduce the pain and discomfort due to a general increase in pain threshold during individual therapeutic and/or diagnostic procedures.

Tramadol, in therapeutic doses, has high pharmacological safety (in comparison with most other opioid analgesics). It does not disturb the blood circulation, it does not inhibit the respiratory function, and it does not modify the pressure in the pulmonary artery.

Side effects

Tramadol has antitussive and sedative effect. This drug can be taken in small dosages for a short time to reduce severe cough.

Relatively high safety of Tramadol is compensated by a weak (compared with morphine) analgesic effect. This drug is much weaker than morphine, but this effect is enough to use for personal purposes. For the average patient, morphine is not available and its use quickly causes dependence.

Tramadol does not result in addiction, and this drug is used for treating withdrawal symptoms of opiates. Tramadol intensively causes tolerance with prolonged use. Opioid receptors get used to the drug and for relief of acute pain; it is required to increase the dosage.

In order not to raise the dosage of Tramadol and reduce the suffering from pain, it is recommended to change the analgesics regularly. The body will not be able to develop tolerance to a drug, as it will be replaced by completely different medications.

Symptomatic treatment of acute pain can help temporarily to relieve the discomfort and suffering, but it is impossible to take Tramadol permanently. You need to find the cause of the pain as quickly as possible and treat it. If you still decide to buy Tramadol, it is required to refer to a doctor.

Uncontrolled and improper use of Tramadol can cause irreversible consequences. The standard single dose of Tramadol is 50 mg. you can take the drug every 6 hours, but not more than 400 mg per day.

In patients with hypersensitivity to Tramadol or severe diseases of the CNS, the dosage should be reduced. The standard dose Tramadol 50 mg within a few days can cause severe adverse symptoms.

Refer to the doctor in advance you think to buy Tramadol, it will give you the chance to escape the harmful effects and effectively deal with unbearable pain.


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